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Respiratory: Asthma & COPD

Asthma Model

 

Part.1 OVA allergen induced mouse asthma model

Test parameters:

  • Airway airflow and lung function: Penh, Ri, Re and Cldyn,
  • Cells count in BALF: total WBC, EOS, NEUT, LYM(%)
  • Igs in serum: Total IgE, allergen sIgE and allergen sIgG1,
  • Pathology: H&E, PAS and Masson staining of lung sections

 

Part.2 OVA induced rats asthma model

Test parameters:

  • Penh (enhanced pause)
  • Inflammatory cells number in BALF
  • Total IgE in serum
  • H&E staining of lung sections

 

Part.3 OVA/HDM induced Guinea pig asthma model;

 

Part.4 OVA allergen induced dog asthma model;

 

Part.5 HDM or Ascaris suum induced macaca fascicularis asthma model;

 

 

COPD (Chronic obstruction pulmonary disease)

 

Part.1 Cigarette smoking inhalation induced rat model of COPD

Test parameters

  • Body weight
  • Lung function index: FEV0.1/FVC, FEV0.3/FVC, Cldyn, Ri, Re
  • Penh
  • H&E staining of lung sections
  • Inflammatory cells count in BALF
  • Cytokines in BALF and plasma: MCP-1, KC, TNF-a

 

 

IPF Model (Model of idiopathic pulmonary fibrosis)

 

Part.1 Intratracheally injection of bleomycin (BLM) induced mouse model of IPF 

Test parameters:

  • Survival proportions
  • Hydroxyproline level
  • H&E staining of lung sections
  • Inflammatory cells number in BALF
  • Penh 

 

 

PAH Model (Pulmonary arterial hypertension)

 

Part.1 Monocrotaline (MCT) induced rat , mini pig and monkey models of PAH

Test parameters:

  1. Body weight
  2. BP (Blood pressure)
  3. RVSP (Right ventricular systolic pressure)
  4. RVHI (Right ventricular hypertrophy index)
  5. Right ventricular function index: RVIDd， RVIDs， RVFS， BFVTV ， PFV
  6. PCNA （Prolifterating cell nuclear antigen staining）
  7. PAWT （Pulmonary arterial wall thickness ）

 

 

OSAHS (Obstructive sleep apnea hypopnea syndrome) Model in DIO Mouse

 

 

Tension of Isolated Tracheal Rings Assay

 

 

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